Published August 29, 2026
| Version 2.1.0 (Chronos)
Software
Open
SimulAdren
Authors/Creators
- 1. Catholic Hospitals Bochum
-
2.
Ruhr University Bochum
-
3.
Klinik Blankenstein
- 4. Lee Kong Chian School of Medicine, Nanyang Technological University Singapore
-
5.
University Hospitals of the Ruhr-University of Bochum
Description
SimulAdren is a continuous simulation program for the hypothalamus-pituitary-adrenal axis (HPA feedback control). It is based on a series of physiology-backed nonlinear MiMe-NoCoDI models and uses the CyberUnits Bricks class library.
Files
SimulAdren_V2_1_0_Handbook_and_Reference.pdf
Files
(46.1 MB)
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Additional details
Identifiers
- RRID
- SCR_027314
- Wikidata
- Q138665214
Related works
- Requires
- Software: 10.5281/zenodo.1304179 (DOI)
- Software: https://dknet.org/data/record/nlx_144509-1/SCR_014360/resolver?q=Free%20Pascal&l=Free%20Pascal&i=rrid:scr_014360 (URL)
- Software: https://dknet.org/data/record/nlx_144509-1/SCR_014362/resolver?q=Lazarus&l=Lazarus&i=rrid:scr_014362 (URL)
Software
- Repository URL
- https://svn.code.sf.net/p/simuladren/svn/
- Programming language
- Pascal
- Development Status
- Active
References
- Dietrich JW, Boehm BO. Equilibrium behaviour of feedback-coupled physiological saturation kinetics. In Trappl R (Editor): Cybernetics and Systems 2006. Austrian Society for Cybernetic Studies. doi: 10.13140/2.1.2400.2568
- Dietrich, JW, Boehm, BO Die MiMe-NoCoDI-Plattform: Ein Ansatz für die Modellierung biologischer Regelkreise. German Med. Sci. Abstr. 284. doi: 10.3205/15gmd s058 (2015)
- Dietrich JW. A Methodology for Vertical Translation Between Molecular and Organismal Level in Biological Feedback Loops. bioRxiv 2021.09.20.461028; doi: 10.1101/2021.09.20.461028
- Dietrich JW, Siegmar N, Hojjati JR, Gardt O, Boehm BO. CyberUnits Bricks – An Implementation Study of a Class Library for Simulating Nonlinear Biological Feedback Loops. Advances in Distributed Computing and Artificial Intelligence Journal. 2024 August; 13. doi: 10.14201/adcaij.31762